Facts about cholesterol Cholesterol is a fat-like, waxy substance that helps your body make cell membranes, many hormones, and vitamin D. Common genetic polymorphisms affect the human requirement for the nutrient choline. Additional drivers of heart disease include diabetes mellitus, hypertension or use of anti-hypertensive medication, low HDL level, family history of coronary artery disease CAD and hypercholesterolemia, and cigarette smoking. Three different mechanisms can form these: autoxidation, secondary oxidation to lipid peroxidation, and cholesterol-metabolizing enzyme oxidation. Cholesterol esters bound to fatty acid, on the other hand, are transported within the fatty hydrophilic core of the lipoprotein, along with triglyceride. Cholesterol has stereoisomers that arise from its 8 stereocenters, although only two of the stereoisomers are of biochemical significance nat -cholesterol and ent -cholesterol, for natural and enantiomer, respectively,   and only one occurs naturally nat -cholesterol. Retrieved 3 April Trans fatty acids—Effects on systemic inflammation and endothelial function.
Instead, the body packages fat and cholesterol into tiny, protein-covered particles called lipoproteins. Lipoproteins can transport a lot of fat; they mix easily with blood and flow with it. Some of these particles are big and fluffy, while others are small and dense. Low-density lipoproteins LDL carry cholesterol from the liver to the rest of the body. Cells latch onto these particles and extract fat and cholesterol from them. When there is too much LDL cholesterol in the blood, these particles can form deposits in the walls of the coronary arteries and other arteries throughout the body. Such deposits, called plaque, can narrow arteries and limit blood flow. When plaque breaks apart, it can cause a heart attack or stroke. Because of this, LDL cholesterol is often referred to as bad, or harmful, cholesterol. High-density lipoproteins HDL scavenge cholesterol from the bloodstream, from LDL, and from artery walls and ferry it back to the liver for disposal.
Where does dietary cholesterol come from still that
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